Virus-Like Particle-Based Countermeasures Against Rift Valley Fever Virus
نویسندگان
چکیده
منابع مشابه
Rift Valley fever virus.
Vet Med Today: Zoonosis Update 883 R Valley fever virus is a mosquito-borne pathogen of livestock and humans that historically has been responsible for widespread and devastating outbreaks of severe disease throughout Africa and, more recently, the Arabian Peninsula. The virus was first isolated and RVF disease was initially characterized following the sudden deaths (over a 4-week period) of ap...
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Rift Valley fever virus (RVFV), a member of the family Bunyaviridae, regularly accounts for large and severe outbreaks among humans and livestock in Africa and Arabia. Therefore, safe and efficient vaccines are highly needed. Here, we report the production of recombinant virus-like particles (VLPs) that, in addition to their similarity to RVFV particles, are able to express the viral nucleocaps...
متن کاملSingle-particle cryo-electron microscopy of Rift Valley fever virus.
Rift Valley fever virus (RVFV; Bunyaviridae; Phlebovirus) is an emerging human and veterinary pathogen causing acute hepatitis in ruminants and has the potential to cause hemorrhagic fever in humans. We report a three-dimensional reconstruction of RVFV vaccine strain MP-12 (RVFV MP-12) by cryo-electron microcopy using icosahedral symmetry of individual virions. Although the genomic core of RVFV...
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ompA: JF803906). All samples were cultured in human embryonic lung fibroblasts as described (6). After 4 weeks, no bacteria were isolated. We report a human case of R. eschlimannii infection in Crete, Greece. Our finding was confirmed by molecular methods. However, we were not able to cultivate R. aeschlimannii from samples collected. This result suggests that living microorganisms may have die...
متن کاملDevelopment and characterization of Rift Valley fever virus-like particles.
Rift Valley fever (RVF) is an acute, febrile zoonotic disease that is caused by the RVF virus (RVFV) and spread by arthropod vectors. RVF is currently prevalent in Africa and the Arabian Peninsula, and causes substantial economic losses. Furthermore, this disease poses a serious threat to animal and human health in regions worldwide, making it a serious public health concern. However, RVFV vacc...
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ژورنال
عنوان ژورنال: Zoonoses and Public Health
سال: 2012
ISSN: 1863-1959
DOI: 10.1111/j.1863-2378.2012.01478.x